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KMID : 0812020060120010035
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Korean Journal of Neurogastroenterology and Motility
2006 Volume.12 No. 1 p.35 ~ p.40
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Clinical Significance of Anti-tissue Transglutaminase as a Screening Method for Celiac Disease in a Korean Population
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Park Jae-Myung
Choi Myung-Gyu
Paik Chang-Nyol
Oh Jung-Hwan
Cho Yu-Kyung
Lee In-Seok
Kim Sang-Woo
Chung In-Sik
Oh Eun-Jee
Park Yeon-Joon
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Abstract
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Background/Aims: Screening for celiac disease is recommended as part of the evaluation for irritable bowel syndrome in the Western countries due to the similarities in symptoms in the two diseases. The aim of this study was to investigate whether screening for celiac disease would be important in patients with functional gastrointestinal (GI) disorders in Korea.
Methods: A total of 694 patients, who visited the GI clinic, were enrolled consecutively. Screening was performed by human recombinant anti-tissue transglutaminase (anti-tTG) IgA ELISA assay.
Results: 128 patients with functional GI disorders, who met the Rome II criteria, and 566 patients with organic GI disorders were subjected to this evaluation. Anti-tTG was positive in six patients (0.86%). None of the six patients met the diagnostic criteria for celiac disease, and the antibody positive results were regarded as false positive results. The final diagnoses for these six patients were: functional dyspepsia, Crohn’s disease, esophageal ulcer, hepatocellular carcinoma, infectious colitis and cholecystitis One patient fulfilled the diagnostic criteria of celiac disease; however, the antibody test was negative in this patient. The specificity of anti-tTG was 99.1%. The antibody tests for all patients with functional colonic disorders were negative.
Conclusions: Screening for celiac disease did not add any benefit to the evaluation of Korean patients with the functional GI disorders. (Kor J Neurogastroenterol Motil 2006;12:35-40)
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KEYWORD
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Celiac disease, Antibody, Transglutaminase, Functional gastrointestinal disorder
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